Ibicuruzwa byinshi Byiza bya Atractylode Amavuta ya Lancea Amavuta Yinganda Zimiti Yumunsi Ibimera Gukuramo Amavuta ya Atractylis

pisthorchis viverrini (OV) -indwara ya cholangiocarcinoma (CCA) ni kanseri ikunze kugaragara hagati y'abagabo n'abagore, cyane cyane muri Tayilande. Ubushakashatsi buherutse gukorwa bwerekanye ko ibivamo Ethanol ya AL byagize ingaruka mbi ku bwoko bw’inyamanswa ya CCA iterwa na OV itagira uburozi bugaragara binyuze mu buyobozi bwo mu kanwa mu gihe cy’iminsi 30 ukurikije ibisubizo byatanzwe na positron emission tomografiya yabazwe na tomografiya hamwe n’abagabo bo muri Siriya [7]. Mu rwego rwo gucukumbura ingaruka za AL rhizome ku mikorere ya gastrointestinal, ubushakashatsi bwakozwe kuri atropine-, dopamine-, na 5-hydroxytryptamine (5-HT) -imbeba zavuwe. Ibisubizo byagaragaje ko ikivamo 1 mg / kg gishobora guhagarika byimazeyo gusiba dopamine iterwa no gusiba no kugabanuka kwa gastrointestinal kugabanuka binyuze mu gutera inshinge. Ibikomoka ku gipimo cya mg / kg 1000 bishobora kugabanya umuvuduko muto wo mu mara uterwa na atropine, kandi ibivamo 500 mg / kg bishobora guhagarika 5-HT iterwa na gastrica no kugabanuka kw amara kugabanuka [8]. Byongeye kandi, AL yagize ingaruka zo kurwanya ibisebe mu buryo bw'imbeba binyuze mu kugabanya abunzi batera umuriro (ni ukuvuga ikibyimba cya necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), na prostaglandine E2 (PGE2) no kongera icyorezo cya epidermal (EGF) hamwe na trefoil factor2 (TFF2) [9]. Ubutaka buterwa n'ubutaka butera 30% umusaruro wibishyimbo [10]. Vuba aha, byavuzwe ko guhuza ibishyimbo, AL bishobora kandi guhashya indwara ziterwa n’ibihumyo ziterwa n’ubutaka binyuze mu kubuzaFusarium oxysporumgukura [11]. Gukuramo peteroli ether (PE) muri AL byagaragaje ingaruka mbi kuri BGC-823 na SGC-7901 ingirabuzimafatizo za kanseri yo mu gifu. Igice cya PE gishobora gutera apoptose, gufatwa kwingirangingo, hamwe na mitochondrial transembrane ishobora guhinduka [12]. Raporo iheruka gushimangira ko ibimera bya MeOH bya AL bishobora kubuza umusaruro wa nitric oxyde (OYA) muri lipopolysaccharide-iterwa na murine macrophage imeze nka RAW264.7 kandi igatera imisemburo ya granulocyte-coloni itera imbaraga (G-CSF) muri selile isanzwe ya epiteliyale MCE301. OYA ni radical yubuntu [13]. Ibikomoka kuri Ethanol ya AL byagize uruhare runini mu kubuza lipase hamwe na IC50 9.06 µg / mL mu isuzuma rya lipase ya pancreatic yumuntu, kandi ryerekanye ingaruka zo kurwanya umubyibuho ukabije ku mavuta y’imbeba nyinshi ziterwa n’imbeba zifite umubyibuho ukabije ku gipimo cya mg 500 / kg [14]. Amazi yakuwe muri AL yerekanaga ibikorwa birwanya kurwanya serotonine yakira hamwe ningaruka zo kubuza guhitamo 5-HT2A / 2C agonist 1- (2,5-dimethoxy-4-iodophenyl) -2-aminopropane-iterwa no kwikuramo imitwe mu mbeba [15]. Amazi ava muri AL yagabanije uburozi buterwa na triptolide binyuze mumabwiriza agenga imiterere ya hepatike ya CYP3A. Hagati aho, AL irashobora kunoza ingaruka zo kurwanya inflammatory ya triptolide. Ubu bushakashatsi bwagaragaje ko AL ishobora guhagarika uburozi no kongera ibikorwa byo kuvura triptolide binyuze mu guhuza