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Ibicuruzwa byinshi Byiza bya Atractylode Amavuta ya Lancea Amavuta Yinganda Zimiti Yumunsi Ibimera Gukuramo Amavuta ya Atractylis
IBISABWA BY'IKORESHWA N'AMAKURU Y’INGENZI: Aya makuru agamije kuzuza, ntasimbuze inama zitangwa na muganga wawe cyangwa umuganga w’ubuzima kandi ntabwo zigamije gukwirakwiza ibintu byose bishoboka, kwirinda, imikoranire cyangwa ingaruka mbi. Aya makuru ntashobora guhura nubuzima bwawe bwihariye. Ntuzigere utinda cyangwa wirengagize gushaka ubuvuzi bwumwuga kwa muganga cyangwa abandi bashinzwe ubuvuzi babishoboye kubera ikintu wasomye kuri WebMD. Ugomba buri gihe kuvugana na muganga wawe cyangwa inzobere mu buvuzi mbere yuko utangira, guhagarika, cyangwa guhindura igice icyo ari cyo cyose cyateganijwe muri gahunda yo kwita ku buzima cyangwa kwivuza no kumenya inzira yo kuvura ikubereye.
Ibi bikoresho byemewe bitangwa nubuvuzi karemano bwububiko bwuzuye bwabaguzi. Amakuru aturuka kuriyi soko ni ibimenyetso bifatika kandi bifite intego, kandi nta bucuruzi bugira. Kumakuru yubuvuzi bwumwuga kumiti karemano, reba Ubuvuzi Kamere Yuzuye Ububikoshingiro Bwumwuga.
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Ibicuruzwa byinshi Byiza bya Atractylode Amavuta ya Lancea Amavuta Yinganda Zimiti Yumunsi Ibimera Gukuramo Amavuta ya Atractylis
Ikimera cya Atractylode lancea niki?
Atractylode lancea ni inkomoko y'Ubushinwa, igihingwa gifite imiti, gihingwa kuri rhizomes. Inkeri zayo zirimo amavuta yingenzi.
Koresha & Inyungu:
Ifite anti-inflammatory, ituza uruhu iyo ushyizwe. Irashobora kuba ingirakamaro kuri acne ikunze, uruhu rurakaye.
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Menthol CamphorBorneol yamavuta Ibirimo Kwiyuhagira na Aromatherapy
Inyungu zubuzima no gukoresha
Borneol itanga ihuriro ryingirakamaro ryubuvuzi bwiburengerazuba nuburasirazuba. Ingaruka za Borneol zirakwiriye mu kuvura indwara zitandukanye. Mubuvuzi bwabashinwa, bujyanye numwijima, spleen meridian, umutima, nibihaha. Hasi nurutonde rwa bimwe mubyiza byubuzima.
Kurwanya indwara z'ubuhumekero n'indwara y'ibihaha
Ubushakashatsi bwinshi bwerekana terpène, na Borneol, cyane cyane bigabanya neza indwara zubuhumekero. Borneol ifiteyerekanye imikoreremukugabanya gucana ibihaha mugabanya cytokine ikongora no gucengera. Abantu bakora ubuvuzi bwabashinwa nabo bakunze gukoresha Borneol kuvura bronhite nindwara zisa.
Anticancer
Borneol nayo yerekanyeanticancermukongera ibikorwa bya Selenocysteine (SeC). Ibi byagabanije kanseri ikwirakwira binyuze mu rupfu rwa kanseri apoptotique (programme). Mu bushakashatsi bwinshi, Borneol yerekanye kandi imikorere yiyongereyeimiti igabanya ubukana.
Gusesengura neza
Muri akwigaurebye ububabare nyuma yo kubagwa mubantu, gukoresha Borneol yibanze byatumye ububabare bugabanuka ugereranije nitsinda rishinzwe kugenzura umwanya. Byongeye kandi, acupuncturiste bakunda gukoresha Borneol hejuru kumiterere yayo idakira.
Igikorwa cyo kurwanya inflammatory
Borneol ifiteyerekanweguhagarika imiyoboro imwe ya ion iteza ububabare no gutwika. Ifasha kandi kugabanya ububabare bwindwara zitera nkarubagimpande.
Ingaruka za Neuroprotective
Borneol itanga uburinzi kuriurupfu rw'uturemangingomugihe habaye ischemic stroke. Yorohereza kandi kuvugurura ingirangingo z'ubwonko no gusana. Birasabwa kugira iyi neuroprotective ingaruka muguhindura permeability yainzitizi y'amaraso.
Kurwanya imihangayiko n'umunaniro
Bamwe mu bakoresha urumogi rufite urugero rwinshi rwa Borneol bavuga ko bigabanya umuvuduko wabo kandi bikagabanya umunaniro, bityo, bigatuma habaho kuruhuka nta mutuzo wuzuye. Abantu bakora ubuvuzi bwabashinwa nabo barabyemeraimbaraga zayo zo kugabanya imbaragal.
Ingaruka zo kwinjira
Kimwe nizindi terpene, ingaruka za Borneol zifatanije nurumogi rwurumogi rwerekanye uIngaruka.Ibi bibaho mugihe ibice bikora hamwe kugirango bitange inyungu zo kuvura. Borneol irashobora kwongerera ubwonko bwamaraso ubwonko, bigatuma byoroha kwanduza molekile zo kuvura muri sisitemu yo hagati.
Usibye imiti myinshi ya Borneol ikoreshwa, irakoreshwa kandi mukurwanya udukoko bitewe nuburozi busanzwe bwibibabi byinshi. Imibavu nayo ikoresha Borneol kubera impumuro yayo nziza kubantu.
Ingaruka zishobora kubaho n'ingaruka zo kuruhande
Borneol ikunze gufatwa nka terpene ya kabiri mu rumogi, bivuze ko igaragara ku rugero ruto. Izi dosiye zo hasi za Borneol zitekereza ko zifite umutekano. Ariko, mugihe kinini cyinshi cyangwa igihe kirekire, Borneol irashobora kugira bimweingaruka zishobora kubaho n'ingaruka mbi, harimo:
- Kurwara uruhu
- Kurakara izuru n'umuhogo
- Kubabara umutwe
- Isesemi no kuruka
- Kuzunguruka
- Umucyo
- Kunanirwa
Hamwe na Borneol igaragara cyane, abantu barashobora kwibonera:
- Kuruhuka
- Imyivumbagatanyo
- Kutitaho ibintu
- Kurwara
- Niba yamizwe, irashobora kuba uburozi cyane
Ni ngombwa kumenya ko amafaranga aboneka mu rumogi adashobora gutera ibi bimenyetso. Kurakara nabyo ntibibaho hamwe na dosiye ntoya ikoreshwa kuri analgesia nizindi ngaruka.
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Amavuta meza ya Cnidii Amavuta ya buji hamwe nisabune akora amavuta menshi ya diffuzeri amavuta yingenzi kubitsa urubingo.
Cnidium ni igihingwa kiva mu Bushinwa. Yabonetse kandi muri Amerika muri Oregon. Imbuto, imbuto, nibindi bice byibimera bikoreshwa nkimiti.
Cnidium yakoreshejwe mu buvuzi gakondo bw'Abashinwa (TCM) mu myaka ibihumbi, akenshi mu bihe by'uruhu. Ntabwo bitangaje kuba cnidium ari ibintu bisanzwe mumavuta yo kwisiga, amavuta, amavuta.
Abantu bafata cnidium kumunwa kugirango bongere imikorere yimibonano mpuzabitsina no gutwara ibitsina, no kuvura imikorere mibi (ED). Cnidium ikoreshwa kandi mubibazo byo kubyara (ubugumba), kubaka umubiri, kanseri, amagufwa adakomeye (osteoporose), n'indwara ya fungal na bagiteri. Abantu bamwe nabo barayifata kugirango bongere ingufu.
Cnidium ikoreshwa muburyo bwuruhu kugirango itere, ibisebe, eczema, hamwe ninzoka.
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Amavuta meza ya parufe yamavuta yimpumuro nziza ya buji nisabune ikora diffuser yamavuta yingenzi amavuta mashya kubitsa urubingo.
Ibigize imiti ya ATR
Ibigize imiti ya ATR ahanini ni ibice bihindagurika nibice bidahindagurika. Amavuta yingenzi ya ATR (ATEO) afatwa nkigice gikora cya ATR, kandi ibikubiye muri ATEO nicyo kimenyetso cyonyine cyo kumenya ibirimo ATR. Kugeza ubu, hari ubushakashatsi butandukanye ku bice bihindagurika kandi ugereranije n'ubushakashatsi buke ku bice bidahindagurika. Ibice bihindagurika birasa naho bigoye, kandi ubwoko bwibanze bwubatswe ni fenylpropanoide (fenilpropanoide yoroshye, lignans na coumarine) na terpenoide (monoterpène, sesquiterpène, diterpenoide na triterpène). Ibice bidahindagurika cyane cyane alkaloide, aldehydes na acide, cinone na ketone, steroli, aside amine, na karubone. Ibisubizo byubushakashatsi bwimiti ya ATR bizagira uruhare mugutezimbere ubushakashatsi bufite ireme.
Ibigize ibintu bihindagurika
Abashakashatsi bifashishije uburyo bwo gupima isesengura nka chromatografiya na GC-MS mu gusesengura ibice bigize imiti ya ATR biva mu nkomoko zitandukanye, ibyiciro bitandukanye, uburyo bwo kuvoma butandukanye n'ibice bitandukanye. Ubushakashatsi bwibanze bwerekanye ko ibintu nyamukuru bigize imiti muri ATR byari amavuta ahindagurika, akaba aricyo kimenyetso cyingenzi cyo gusuzuma ubuziranenge bwa ATR. α-Asarone na β-asarone bangana na 95% by'amavuta ahindagurika ya ATR kandi byagaragaye nkibigize ibiranga (Igishushanyo 1) ((Intama n'abandi., 2016a). “Pharmacopoeia yo muri Repubulika y’Ubushinwa” (2020 Edition) yanditse ko amavuta ahindagurika muri ATR atagomba kuba munsi ya 1.0% (mL / g). Kugeza ubu, ubwoko bwinshi bwibigize amavuta yabonetse muri ATR
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Amavuta meza ya parufe yamavuta yimpumuro nziza ya buji nisabune ikora diffuser yamavuta yingenzi amavuta mashya kubitsa urubingo.
Perilla ni icyatsi. Ikibabi n'imbuto bikoreshwa mugukora imiti.
Perilla ikoreshwa mu kuvura asima. Ikoreshwa kandi mu kugira isesemi, izuba ryinshi, gutera ibyuya, no kugabanya imitsi.
Mu biryo, perilla ikoreshwa nkuburyohe.
Mu gukora, amavuta yimbuto ya perilla akoreshwa mubucuruzi mugukora langi, amarangi, na wino.
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Amavuta meza ya parufe yamavuta yimpumuro nziza ya buji nisabune ikora diffuser yamavuta yingenzi amavuta mashya kubitsa urubingo.
Angelica ni igihingwa. Umuzi, imbuto, n'imbuto bikoreshwa mugukora imiti.
Angelica ikoreshwa mu gutwika umutima, gaze yo mu nda (flatulence), kubura ubushake bwo kurya (anorexia), arthrite, ibibazo byo gutembera, “izuru ritemba” (catarrh y'ubuhumekero), guhagarika umutima, icyorezo, hamwe no gusinzira (kudasinzira).
Abagore bamwe bakoresha angelica kugirango batangire imihango. Rimwe na rimwe, ibi bikorwa kugirango bakuremo inda.
Angelica ikoreshwa kandi mu kongera umusaruro w'inkari, kunoza imibonano mpuzabitsina, kuzamura umusaruro no gusohora kwa flegm, no kwica mikorobe.
Abantu bamwe bakoresha angelica muburyo bwuruhu kubabara imitsi (neuralgia), kubabara ingingo (rheumatisme), hamwe nindwara zuruhu.
Hamwe nibindi bimera, angelica nayo ikoreshwa mukuvura gusohora imburagihe.
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100% Amavuta meza ya Cyperus Amavuta meza yo gukora isabune yo gukora amavuta ya Cyperus Rotundus
Nutgrass nicyatsi kizwi gikoreshwa muburyo bwiza bwo kuvura uruhu. Nkuko Ayurveda ibivuga, yakoreshejwe mumashusho atandukanye yari yiteguye koroshya ibibara byijimye nibindi.
Inyungu…
Byagaragaye kandi mu miti myinshi ya Ayurvedic yo kuvura ibisebe, indwara zandurira hamwe nindwara zuruhu. Ifu yifu yumuzi wa Nutgrass irakomeye cyane kandi ikungahaye kuri antioxydants, ifasha kugabanya gusaza kwuruhu kuko ikora kugirango igabanye imirongo myiza niminkanyari. Ifasha kugenzura imiterere ikabije ya pigment, melanin, muruhu. Gutyo, igarura isura nziza yuruhu. Ibinyomoro bikonje muri kamere, umutungo wacyo urwanya inflammatory bifasha kugabanya umutuku, gucika, hamwe nuruhu rwaka. Yagaragaje kuvura indwara zikomeye zuruhu. Ikungahaye kuri aside irike, vitamine na flavonoide bifitiye akamaro kanini uruhu ndetse n umusatsi. Iyi mico yongerera urumuri rwuruhu, kandi ikomeza umusatsi hamwe nubunini nubunini.
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Amavuta meza meza ya Notopterygium yamavuta akoreshwa mubuvuzi
Mu rwego rwo kwirukana umuyaga no gukuraho ububobere, hari ibyatsi byinshi byabashinwa babishoboye. Kubwibyo, kugereranya notopterygium hamwe nabagenzi bayo bafite imiti isa yo gukiza byadufasha kumva neza iki gihingwa cyimiti.
Imizi ya notopterygium n'umuzi wa Angelica (Du Huo) irashobora gukuraho umuyaga-mwuka no kunoza ububabare hamwe no gukomera. Ariko bafite imbaraga zabo n'intege nke zabo. Iyambere hamwe na kamere hamwe nuburyohe bukomeye, bigatuma igira ingaruka nziza ya antipyretike binyuze mu kubira ibyuya no kuzamuka kwimbaraga. Kubera iyo mpamvu, nicyatsi cyiza cyindwara zumugongo nububabare mumubiri wo hejuru ninyuma yumutwe. Mugereranije, imizi ya angelica hamwe nimbaraga zimanuka, ziha imbaraga nziza zo gukiza indwara ya rubagimpande yumubiri wo hasi hamwe nububabare bufatanye mumaguru, umugongo wo hepfo, ukuguru, na shin. Nkigisubizo, bakunze gukoreshwa mubuvuzi kuva byuzuzanya cyane.
Byombi notopterygium naGui Zhi (Ramulus Cinnamomi)nibyiza kwirukana umuyaga no gukuraho imbeho. Ariko ibyo byambere bikunda umuyaga mwinshi mumutwe, ijosi, ninyuma mugiheGui Zhinibyiza guhangana numuyaga-mwinshi mubitugu, amaboko, nintoki.
Bothe notopterygium naFang Feng (Radix Saposhnikoviae)kabuhariwe mu kwirukana umuyaga. Ariko iyambere ifite ingaruka zikomeye kurenza Fang Feng.
Ibikorwa bya farumasi bigezweho byumuzi wa notopterygium
1. Gutera inshinge bigira ingaruka zidasanzwe na antipyretic. Byongeye kandi, ifite kubuza ibihumyo byuruhu na brucellose;
2. Igice cyacyo gishonga gifite ingaruka zo kurwanya anti-arththmic;
3. Amavuta yacyo ahindagurika kandi afite ingaruka zo kurwanya inflammatory, analgesic na antipyretic. Kandi irashobora kurwanya isitemiya ya myocardial iterwa na pituitrin kandi ikongera amaraso yintungamubiri ya myocardial;
4. Amavuta yacyo ahindagurika aracyabuza ubwoko bwatinze cyane bwimbeba.Icyitegererezo notopterygium incisum resept kumiti y'ibyatsi
Zhong Guo Yao Dian (pharmacopoeia yo mu Bushinwa) yizera ko ari acrid kandi ikarishye muburyohe kandi bushyushye muri kamere. Irimo meridian y'uruhago n'impyiko. Ibikorwa nyamukuru ni ukwirukana umuyaga, kwirukana imbeho, gukuraho ububobere, no kugabanya ububabare. Shingiro rya notopterygium ikoresha nibimenyetso birimokubabara umutwemu bwoko bukonjeubukonje busanzwe, rubagimpande, n'ububabare bubabaza ibitugu n'umugongo. Igipimo gisabwa ni kuva kuri garama 3 kugeza kuri 9.
1. Qiang HuoFu ZiTang kuva Yi Xue Xin Wu (Ibyahishuwe mubuvuzi). Yahujwe na Fu Zi (Aconite),Gan Jiang(Ginger yumyeImizi), na ZhiGan Cao.
2. Jiu Wei Qiang Huo Tang kuvaCi ShiNan Zhi (Ubumenyi bukomeye). Yateguwe na Fang Feng, Xi Xin (Herba Asari),Chuan Xiong(umuzi), nibindi kugirango ukize ubwoko bwumuyaga ukonje wanduye uherekejwe nubushuhe, gukonja, umuriro, nta icyuya, kubabara umutwe,ijosi rikomeye, n'ububabare bukabije bw'ingingo mu ngingo.
3. Ikoreshwa hamwe numuzi wa angelica,Gao Ben(Rhizoma Ligustici), Fang Feng, etc.
4. Juan Bi Tang, uzwi kandi nka notopterygium naturmericguhuza, uhereye kuri Bai Yi Xuan Fang (Byatoranijwe neza-Byanditswe). Ikorana na Fang Feng, Jiang Huang (Curcuma Longa),Dang Gui(Dong Quai), etc.
5. Qiang Huo Gong Gao Tang wo muri Shen Shi Yao Han (Igitabo Cyiza cyaUbuvuzi bw'amaso). Ihuza n'umuzi wa lovage,Bai Zhi(Angelica Dahurica), Rhizoma Ligustici, nibindi byo kugabanya ububabare bwumutwe uterwa numuyaga ukonje cyangwa umuyaga.
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Amavuta meza ya Aucklandia ya buji ya buji hamwe nisabune ikora amavuta menshi ya diffuser amavuta yingenzi kubitsa urubingo.
Osteoarthritis (OA) ni imwe mu ndwara zifata igihe kirekire zidakira zifata amagufwa yibasira abaturage bageze mu za bukuru barengeje imyaka 65 [1]. Muri rusange, abarwayi ba OA basuzumwa na karitsiye yangiritse, synovium yaka umuriro, na chondrocytes yangirika, itera ububabare nububabare bwumubiri [2]. Ububabare bwa rubagimpande buterwa ahanini no kwangirika kwa karitsiye mu ngingo hamwe no gutwikwa, kandi iyo karitsiye yangiritse cyane amagufwa arashobora kugongana bitera ububabare butihanganirwa ndetse nububabare bwumubiri [3]. Uruhare rwabunzi batera ibimenyetso nibimenyetso nkububabare, kubyimba, no gukomera kwingingo byanditse neza. Mu barwayi ba OA, cytokine ikongora, itera isuri ya karitsiye hamwe namagufa ya subchondral iboneka mumazi ya synovial [4]. Ibibazo bibiri by'ingenzi abarwayi ba OA bafite muri rusange ni ububabare no gutwika synovial. Kubwibyo intego yibanze yubuvuzi bwa OA nubu ni ukugabanya ububabare no gutwikwa. [5]. Nubwo imiti ya OA iboneka, harimo imiti itari steroidal na steroidal, byagaragaye ko ifite akamaro mu kugabanya ububabare n’umuriro, gukoresha igihe kirekire iyi miti bigira ingaruka zikomeye ku buzima nk’umutima, imitsi, gastro-amara, ndetse n’imikorere mibi y’impyiko [6]. Niyo mpamvu, imiti ikora neza ifite ingaruka nkeya igomba gutezwa imbere yo kuvura osteoarthritis.Ibicuruzwa byubuzima bisanzwe bigenda byamamara kubera umutekano kandi byoroshye kuboneka [7]. Imiti gakondo ya koreya yerekanye akamaro ko kurwanya indwara nyinshi zitera, harimo na rubagimpande [8]. Aucklandia lappa DC. azwiho imiti yubuvuzi, nko kongera umuvuduko wa qi kugirango ugabanye ububabare no koroshya igifu, kandi wakoreshejwe gakondo nka analgesic naturel [9]. Raporo zabanjirije iyi zerekana ko A. lappa ifite anti-inflammatory [10,11], analgesic [12], anticancer [13], na gastroprotective [14] ingaruka. Ibikorwa bitandukanye byibinyabuzima bya A. lappa biterwa nibintu byingenzi bikora: costunolide, lahydone dehydrocostus, dihydrocostunolide, costuslactone, α-costol, saussurea lactone na costuslactone [15]. Ubushakashatsi bwakozwe mbere buvuga ko costunolide yerekanaga imiti igabanya ubukana muri lipopolysaccharide (LPS), itera macrophage binyuze mu mabwiriza ya NF-kB hamwe n’ubushyuhe bwa poroteyine.16,17]. Ariko, nta bushakashatsi bwigeze bukora ubushakashatsi kubikorwa bya A. lappa yo kuvura OA. Ubu bushakashatsi bwakoze ubushakashatsi ku ngaruka zo kuvura A. lappa kurwanya OA ukoresheje (monosodium-iodoacetate) MIA hamwe na acide acike iterwa na moderi yimbeba.Monosodium-iodoacetate (MIA) ikoreshwa cyane mu kubyara imyitwarire myinshi y'ububabare hamwe na patrophysiologique ya OA mu nyamaswa [18,19,20]. Iyo MIA yatewe mu mavi, MIA itesha agaciro metabolisme ya chondrocyte kandi igatera ibimenyetso byerekana umuriro, nka karitsiye hamwe nisuri yamagufwa ya subchondral, ibimenyetso byingenzi bya OA [18]. Igisubizo cyanditse cyatewe na acide acetike gifatwa nkikigereranyo cyububabare bwa periferique ku nyamaswa aho ububabare bwakongejwe bushobora gupimwa ku bwinshi.19]. Imbeba macrophage selile umurongo, RAW264.7, ikoreshwa cyane mukwiga ibisubizo bya selile kumuriro. Iyo ukorana na LPS, macrophage ya RAW264 ikora inzira yumuriro kandi ikarekura abahuza benshi, nka TNF-α, COX-2, IL-1β, iNOS, na IL-6 [20]. Ubu bushakashatsi bwasuzumye ingaruka zo kurwanya nociceptive na anti-inflammatory ya A. lappa irwanya OA mu cyitegererezo cy’inyamanswa ya MIA, icyitegererezo cy’inyamanswa iterwa na acide, na selile RAW264.7.2. Ibikoresho nuburyo bwiza
2.1. Ibikoresho by'ibihingwa
Umuzi wumye wa A. lappa DC. yakoreshejwe mu igeragezwa yaguzwe muri Epulip Pharmaceutical Co., Ltd., (Seoul, Koreya). Yagaragajwe na Prof. Donghun Lee, Umuyobozi w’imiti y’imiti y’ibyatsi, Col. w’ubuvuzi bwa Koreya, kaminuza ya Gachon, kandi nimero yerekana inyemezabuguzi yashyizwe mu 18060301.2.2. HPLC Isesengura rya A. lappa Ikuramo
A. lappa yakuweho hakoreshejwe ibikoresho byo kugaruka (amazi yatoboye, 3 h kuri 100 ° C). Igisubizo cyakuweho cyayungurujwe kandi cyegeranye hifashishijwe moteri yumuvuduko muke. A. ikuramo rya lappa ryagize umusaruro wa 44,69% nyuma yo gukama-gukama munsi ya −80 ° C. Isesengura rya Chromatografique ya A. lappa ryakozwe na HPLC ihujwe hakoreshejwe sisitemu ya 1260 InfinityⅡ HPLC (Agilent, Pal Alto, CA, USA). Gutandukanya chromatic, EclipseXDB C18 inkingi (4,6 × 250 mm, 5 µm, Agilent) yakoreshejwe kuri 35 ° C. Igiteranyo cya mg 100 cyikigereranyo cyavanze muri mL 10 ya 50% methanol hanyuma ikabyara iminota 10. Ingero zayungurujwe hamwe na filteri ya siringi (Amazi Corp., Milford, MA, USA) ya 0.45 mm. Igice cya mobile kigizwe na 0.1% acide fosifori (A) na acetonitrile (B) hanyuma inkingi yavuzwe kuburyo bukurikira: 0-60 min, 0%; Iminota 60-65, 100%; Iminota 65-67, 100%; 67-72 min, 0% solvent B hamwe nigipimo cya 1.0 mL / min. Amazi yagaragaye kuri 210 nm akoresheje inshinge ya 10 μL. Isesengura ryakozwe muri bitatu.2.3. Imiturire ninyamaswa
Imbeba Zigitsina gabo - Dawley (SD) zifite ibyumweru 5 nimbeba za ICR zumugabo zifite ibyumweru 6 zaguzwe muri Samtako Bio Korea (Gyeonggi-do, Koreya). Amatungo yabitswe mucyumba akoresheje ubushyuhe buhoraho (22 ± 2 ° C) nubushuhe (55 ± 10%) hamwe n’umucyo / umwijima wa 12/12 h. Inyamaswa zari zimenyereye imiterere mugihe kirenze icyumweru mbere yuko ubushakashatsi butangira. Amatungo yari afite ad libitum itanga ibiryo n'amazi. Amategeko agenga imyitwarire yubu yo kwita ku nyamaswa no gufata neza muri kaminuza ya Gachon (GIACUC-R2019003) yakurikijwe cyane muburyo bwose bwo kugerageza inyamaswa. Ubushakashatsi bwateguwe nubushakashatsi buhumye kandi bubangikanye. Twakurikije uburyo bwa euthanasiya dukurikije umurongo ngenderwaho wa komite ishinzwe imyitwarire yinyamaswa.2.4. Gutera inshinge no kuvura
Imbeba zatandukanijwe muburyo butandukanye mumatsinda 4, arizo sham, kugenzura, indomethacine, na A. lappa. Kuba anesthete hamwe na 2% isofluorane O2 ivanze, imbeba zatewe inshinge 50 μL za MIA (40 mg / m; Sigma-Aldrich, St. Ubuvuzi bwakozwe nkibi bikurikira: kugenzura amatsinda ya sham byakomezaga gusa nimirire yibanze ya AIN-93G. Gusa, itsinda rya indomethacin ryahawe indomethacine (3 mg / kg) yinjijwe mu ndyo ya AIN-93G naho itsinda rya A. lappa 300 mg / kg ryahawe indyo ya AIN-93G yongerewe na A. lappa (300 mg / kg). Ubuvuzi bwakomeje iminsi 24 uhereye umunsi OA yinjiriye ku gipimo cya 15-17 g ku buremere bw'umubiri wa 190-210 g buri munsi.2.5. Ibipimo byo gupima ibiro
Nyuma yo kwinjizwa kwa OA, gupima ubushobozi bwo gupima uburemere bwinyuma yinyuma yimbeba byakozwe hamwe nubushobozi buke-MeterTester600 (IITC Life Science, Woodland Hills, CA, USA) nkuko byari byateganijwe. Ikwirakwizwa ryibiro ku ngingo zinyuma ryabazwe: ubushobozi bwo gutwara ibiro (%) -
Umushinwa Angelica Dahurica Imizi Ikuramo Amavuta ya Massage
Imikoreshereze ya Angelica
Ikoreshwa ry'inyongera rigomba kuba ryihariye kandi rigasuzumwa ninzobere mu by'ubuzima, nk'umuganga w’imirire wanditswe, umufarumasiye, cyangwa utanga ubuvuzi. Nta nyongera igamije kuvura, gukiza, cyangwa gukumira indwara.
Ibimenyetso bikomeye bya siyansi bishyigikira ikoreshwa rya Angelica birabuze. Kugeza ubu, byinshi mubushakashatsi kuriAngelica archangelicayakorewe ku cyitegererezo cy'inyamaswa cyangwa muri laboratoire. Muri rusange, hakenewe ibigeragezo byinshi byabantu ku nyungu zishobora guterwa na Angelica.
Ibikurikira nukureba icyo ubushakashatsi buriho buvuga kubyerekeye ikoreshwa rya Angelica.
Nocturia
Nocturiani imiterere isobanurwa nkukeneye gukanguka ibitotsi inshuro imwe cyangwa nyinshi buri joro kugirango inkari. Angelica yizwe kugirango ikoreshwe mu kugabanya nocturia.
Mu bushakashatsi bumwe-buhumye, abitabiriye nocturia bahawe igitsina gabo bakivuka bahisemo kwakira aUmwanya(ibintu bidakora) cyangwa ibicuruzwa bikozwe muriAngelica archangelicaikibabi mu byumweru umunani.4
Abitabiriye amahugurwa basabwe gukurikirana iminsi yose iyoinkari. Abashakashatsi basuzumye buri munsi haba mbere na nyuma yo kuvura. Ubushakashatsi burangiye, abafashe Angelica bavuze ko hari ubusa buke bwijoro (bakeneye kubyuka mu gicuku kugira ngo biyuhagire) kurusha abafashe ikibanza, ariko itandukaniro ntiryari rikomeye.4
Kubwamahirwe make, ubundi bushakashatsi buke bwakozwe kugirango hamenyekane niba Angelica ishobora guteza imbere nocturia. Ubushakashatsi burakenewe muri uru rwego.
Kanseri
Mugihe nta nyongera cyangwa ibyatsi bishobora gukirakanseri, hari inyungu muri Angelica nkubuvuzi bwuzuzanya.
Abashakashatsi bakoze ubushakashatsi ku ngaruka zishobora gutera antikanseri muri laboratoire. Muri bumwe muri ubwo bushakashatsi, abashakashatsi barageragejeAngelica archangelicagukuramokanseri y'ibereselile. Basanze Angelica ashobora gufasha gutera kanseri y'ibere ingirabuzimafatizo, bigatuma abashakashatsi bemeza ko ibyatsi bishobora kugiraantitumorubushobozi.5
Ubushakashatsi bwakera cyane bwakorewe ku mbeba bwabonye ibisubizo bisa.6 Ariko, ibisubizo ntabwo byiganye mubigeragezo byabantu. Hatabayeho ibigeragezo byabantu, nta kimenyetso cyerekana ko Angelica ashobora gufasha kwica kanseri ya muntu.
Amaganya
Angelica yakoreshejwe mubuvuzi gakondo nkumuti waguhangayika. Ariko, ibimenyetso bya siyansi bishyigikira iki kirego ni bike.
Kimwe nubundi buryo bwo gukoresha Angelica, ubushakashatsi ku mikoreshereze yabwo mu guhangayika bwakozwe ahanini muri laboratoire cyangwa ku nyamaswa.
Mu bushakashatsi bumwe, ibice bya Angelica byahawe imbeba mbere yo gukoraguhangayikaibizamini. Abashakashatsi bavuga ko imbeba zakoze neza nyuma yo kwakira Angelica, bigatuma zishobora kuvurwa amaganya.7
Ibigeragezo byabantu nubushakashatsi bukomeye birasabwa kugirango umenye uruhare rwa Angelica mukuvura amaganya.
Indwara ya mikorobe
Bivugwa ko Angelica afite imiti igabanya ubukana, ariko ubushakashatsi bwakozwe n'abantu bwakozwe neza ntabwo bwakozwe kugirango hemezwe iki kirego.
Abashakashatsi bamwe bavuga ko Angelica agaragaza ibikorwa bya mikorobe birwanya: 2
- Clostridium diffile (C. itandukaniro)
- Clostridium perfringens
- Enterococcus faecalis
- Eubacterium limosum
- Peptostreptococcus anaerobius
- Candida albicans
Nyamara, imirongo mike iratangwa kubyerekeranye nuburyo Angelica ishobora kubuza izo bagiteri nizindi.
Ibindi Byakoreshejwe
Mu buvuzi gakondo,Angelica archangelicaikoreshwa mu kuvura izindi ndwara, harimo: 1
Ibimenyetso bifatika bya siyansi bishyigikira ibyo gukoresha ni bike. Witondere kuvugana nubuvuzi mbere yo gukoresha Angelica kubi nibindi bibazo byubuzima.
Ni izihe ngaruka zo kuruhande rwa Angelica?
Kimwe nicyatsi cyangwa inyongeramusaruro, Angelica irashobora gutera ingaruka mbi. Ariko, kubera kubura ibigeragezo byabantu, habaye raporo nke zingaruka zishobora guterwa na Angelica.
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Amavuta meza ya magnoliya asanzwe amavuta ya flos magnoliae yamavuta ya parufe
Magnoliae Flos ni ibikoresho bisanzwe bivura imiti muri Aziya. Ikoreshwa mukuvura sinusite, kunanuka kwizuru, hamwe nuruhu rwinshi. Kubera ko Magonlia Flos yasobanuwe nk'ibintu bihumura neza mu nyandiko za kera z'Abashinwa, twavuze ko amavuta ya ngombwa ashobora gukoreshwa mu kuvura indwara z'umubiri. Ingirabuzimafatizo ya Dendritic (DCs), ifatwa nkintego nyamukuru y’ubudahangarwa bw'umubiri kugira ngo igenzure ubudahangarwa bw'umubiri, igira uruhare runini mu kurwanya ubudahangarwa bw'umubiri. Muri ubu bushakashatsi, amavuta ya ngombwa ya Magnoliae Flos (MFEO) yagabanije umusaruro wa cytokine TNF- α, IL-6, na IL-12p70 muri lipopolysaccharide (LPS) -yerekana DC. Yahagaritse kandi ibimenyetso byerekana hejuru ya MHC II, CD80, na CD86 muri DC ikangurwa na LPS. Icyitegererezo cy’inyamaswa cyerekanye ko 2,4-Dinitro-1-fluorobenzene (DNFB) itera umubyibuho ukabije wabujijwe nyuma yo kuvurwa na MFEO. Byongeye kandi, MFEO yabujije kwinjira muri selile T mumatwi yimbeba zatewe na DNFB. Kugirango ushakishe ibinyabuzima byacyo, ibice bya MFEO byasesenguwe hakoreshejwe gazi chromatografiya (GC) na GC-mass spectrometry. Ibisubizo byagaragaje ko ibice byingenzi muri MFEO ari camphor na 1.8-cineole. Ibindi bioassay ya DC yemeje ko ibyo bikoresho byahagaritse cyane umusaruro wa cytokine muri DC iterwa na LPS. Kubwibyo, twerekanye ko MFEO igaragaza ingaruka zubudahangarwa haba muri vivo ndetse no muri vitro, kandi camphor na 1.8-cineole bishobora kuba ibice byingenzi bishinzwe ubushobozi bwikingira. Ibyavuye mu bushakashatsi byerekana ko MFEO ifite ubushobozi bwo gutezwa imbere nka immunosuppressant nshya y’indwara zikabije.
