OEM Custom Package Kamere ya Macrocephalae Amavuta ya Rhizoma

ibisobanuro bigufi:

Nkumuti mwiza wa chimiotherapeutique, 5-fluorouracil (5-FU) ikoreshwa cyane mukuvura ibibyimba bibi mumitsi yigifu, umutwe, ijosi, igituza, nintanga ngore. Kandi 5-FU numuti wambere kumurongo wa kanseri yibara mumavuriro. Uburyo bwibikorwa bya 5-FU nuguhagarika ihinduka rya acide nucleic acide ya acide ya thymine nucleic acide yibibyimba, hanyuma bikagira ingaruka kuri synthesis no gusana ADN na RNA kugirango bigere ku ngaruka za cytotoxic (Afzal et al., 2009; Ducreux et al., 2015; Longley n'abandi, 2003). Nyamara, 5-FU itanga kandi chimiotherapie iterwa n'impiswi (CID), imwe mu ngaruka mbi zikunze kwibasira abarwayi benshi (Filho et al., 2016). Umubare w'impiswi ku barwayi bavuwe na 5-FU wageze kuri 50% - 80%, ibyo bikaba byaragize ingaruka zikomeye ku iterambere n'imikorere ya chimiotherapie (Iacovelli et al., 2014; Rosenoff et al., 2006). Kubwibyo, ni ngombwa cyane gushakisha uburyo bwiza bwo kuvura 5-FU iterwa na CID.

Kugeza ubu, ibiyobyabwenge bidafashwe n’ibiyobyabwenge byinjijwe mu buvuzi bwa CID. Ibikorwa bitarimo ibiyobyabwenge birimo indyo yuzuye, no kongeramo umunyu, isukari nintungamubiri. Ibiyobyabwenge nka loperamide na octreotide bikoreshwa cyane mu kuvura anti-diarrhea ivura CID (Benson et al., 2004). Byongeye kandi, Ethnomedicines nayo yemewe kuvura CID hamwe nubuvuzi bwabo bwihariye mubihugu bitandukanye. Ubuvuzi gakondo bw'Abashinwa (TCM) ni bumwe mu bwoko bwa Ethnomedicine bumaze imyaka irenga 2000 bukorwa mu bihugu bya Aziya y'Uburasirazuba harimo Ubushinwa, Ubuyapani na Koreya (Qi et al., 2010). TCM ivuga ko imiti ya chimiotherapeutique yatera Qi kurya, kubura intanga, kutagira igifu no kugabanuka kwa endofitike, bikaviramo gukora nabi amara. Mu nyigisho za TCM, ingamba zo kuvura CID zigomba ahanini gushingira ku kuzuza Qi no gukomeza ururenda (Wang et al., 1994).

Imizi yumye yaAtractylode macrocephalaKoidz. (AM) naPanax ginsengCA Mey. (PG) ni imiti isanzwe y'ibyatsi muri TCM hamwe n'ingaruka zimwe zo kuzuza Qi no gukomeza ururenda (Li et al., 2014). AM na PG mubisanzwe bikoreshwa nkibimera (uburyo bworoshye bwo guhuza ibimera byabashinwa) hamwe ningaruka zo kuzuza Qi no gukomeza ururenda rwo kuvura impiswi. Kurugero, AM na PG byanditswe muburyo bwa kera bwo kurwanya impiswi nka Shen Ling Bai Zhu San, Si Jun Zi Tang kuvaTaiping Huimin Heji Ju Fang(Ingoma yindirimbo, Ubushinwa) na Bu Zhong Yi Qi Tang kuvaPi Wei Lun(Ingoma ya Yuan, Ubushinwa) (Ishusho 1). Ubushakashatsi bwinshi bwibanze bwari bwaravuze ko formula zose uko ari eshatu zifite ubushobozi bwo kugabanya CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Byongeye kandi, ubushakashatsi bwatubanjirije bwerekanye ko Shenzhu Capsule irimo AM na PG gusa igira ingaruka zishobora kuvura imiti yimpiswi, kolite (syndrome ya xiexie), nizindi ndwara zifata igifu (Feng et al., 2018). Ariko, nta bushakashatsi bwigeze buganira ku ngaruka nuburyo bwa AM na PG mu kuvura CID, haba hamwe cyangwa wenyine.

Noneho amara microbiota afatwa nkikintu gishobora gusobanukirwa uburyo bwo kuvura TCM (Feng et al., 2019). Ubushakashatsi bugezweho bwerekana ko microbiota yo munda igira uruhare runini mukubungabunga amara homeostasis. Microbiota nzima igira uruhare mukurinda amara, metabolisme, immunostasis yumubiri nigisubizo, hamwe no guhagarika indwara (Thursdayby na Juge, 2017; Pickard et al., 2017). Indwara ya microbiota idahwitse yangiza imikorere yumubiri nubudahangarwa bwumubiri wumuntu muburyo butaziguye cyangwa butaziguye, bitera ingaruka zimpiswi nka diarrhea (Patel et al., 2016; Zhao na Shen, 2010). Ubushakashatsi bwerekanye ko 5-FU yahinduye ku buryo budasanzwe imiterere ya microbiota yo mu nda mu mbeba za diarrheic (Li et al., 2017). Kubwibyo, ingaruka za AM na PM kuri 5-FU zatewe nimpiswi zirashobora guhuzwa na microbiota yo munda. Ariko, niba AM na PG byonyine kandi hamwe bishobora gukumira 5-FU iterwa nimpiswi muguhindura mikorobe yo mu nda ntikiramenyekana.

Kugirango dukore iperereza ku ngaruka zo kurwanya impiswi hamwe nuburyo bwibanze bwa AM na PG, twakoresheje 5-FU twigana urugero rwimpiswi mu mbeba. Hano, twibanze ku ngaruka zishobora guterwa nubuyobozi bumwe kandi buhuriweho (AP) bwaAtractylode macrocephalaamavuta ya ngombwa (AMO) naPanax ginsengsaponine yuzuye (PGS), ibice bikora byakuwe muri AM na PG, kumpiswi, indwara zo munda hamwe na mikorobe nyuma ya chimiotherapie 5-FU.